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In the EMPA-REG OUTCOME study with empagliflozin [54], the ARR was 1.4%, and the HR 0.65 (95% CI 0.50, 0.85) and in the CANVAS Program with canagliflozin the HR was 0.67 (95% CI 0.52, 0.87), with a rate of hospitalised HF of 5.5 vs 8.7 events per 1000 patient-years [55]

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doi: 10.3389/fonc.2022.868351 59 LiDZhang M and ChaoH

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