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7 Future perspectives Despite the promising potential of GLP-1RAs for the treatment of AF by targeting EAT, numerous significant challenges remain for their clinical translation

doi: 10.1111/j.1743-6109.2010.01991.x 68 CarrM

Most are weekly injections, but oral formulations are becoming available

Neuroprotection by exendin-4 is GLP-1 receptor specific but DA D3 receptor dependent, causing altered BrdU incorporation in subventricular zone and substantia nigra

Peripherally administrated GLP-1RA may also indirectly act on the brain by binding to GLP-1Rs on vagal afferent parasympathetic nerve endings, thereby generating and transmitting satiety signals to the hypothalamus and hindbrain (19)

Strengths and limitations of this review We have comprehensively reviewed the current body of evidence and have combined all data available to us regarding the safety of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation