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GLP-1 RAs in Steatotic Liver Disease (MASLD, MetALD, and ALD) Although not yet specifically approved for the treatment of MASLD, GLP-1 RAs exhibit pleiotropic effects that contribute to the improvement of MASLD and its progression to metabolic dysfunction-associated steatohepatitis (MASH) (Table 3)

Supplies and preparation Injection supplies: Insulin syringes (typically 0.5mL or 1mL with 29-31 gauge needles) for subcutaneous injection

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Recent Developments 10.5.6

L.LyuX.ChenX.WeiW.AbbasiF.et al (2024)

According to the longest available trial on the compound, the most commonly experienced side effects include [16]: Increase in appetite (67%) Joint pain (58%) Mild lower extremity edema (44%) Mild muscle pain (33%) The researchers reported that all of these complaints subsided within a few months of discontinuing MK-677 therapy [16]