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While their biochemical pathways differ, both reduce hunger and increase satiety, creating redundancy rather than synergy

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For example, the stiffened ECM in cancerous tissues prevents immune cell migration and function, leading to impairment of the immune response

A 2023 study showed individuals with obesity have hyperactive brain regions (e.g., hypothalamus, reward centers) when exposed to food, making high-calorie options feel irresistible

Just like retinol, the acidity destabilizes peptide bonds