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The water-soluble nature means that passive diffusion can occur when very high doses are consumed orally , which is why high-dose oral supplements (1,0002,000 micrograms) can be effective even in patients with impaired intrinsic factor production

Reported side effects are generally mild and include temporary gastrointestinal discomfort, headaches during initial use, occasional fatigue as the body adjusts, and rare nausea, especially when taken without food

Table of Contents Toggle This is a well-documented fact: Vitamin B12 deficiency has a great impact on your skin, and you may experience many problems that will transform its look and feel

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This can be a valuable enhancement for someone already experiencing joint pain, mild osteoarthritis, or some sports-related damage

doi: 10.1007/BF01537272