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The more recent REDUCE-IT trial (n = 8,179) found that 4 g/day of icosapent ethyl (a purified eicosapentaenoic acid ethyl ester) significantly reduced cardiovascular death (HR 0.75, 95% CI 0.680.83), myocardial infarction, and stroke in high-risk individuals with elevated triglycerides despite statin therapy

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Care 32 , 10231025 (2009)

Much of it is excreted through urine

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Rare but serious events have been reported, including prolonged erections/priapism, systemic reactions, neurological symptoms, kidney-related complications, and melanoma or concerning skin changes