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Currently, the modulation of intestinal microbiota through microecological therapies, including probiotics, prebiotics, and fecal microbiota transplantation, is a prominent area of clinical investigation for preventing and managing hyperuricemia and gout

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In the field of immunological research, PBMC are a valuable cell type in vivo as well as ex vivo , to examine cellular metabolism under different conditions (13)

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In addition, M1 enhances uric acid reabsorption through URAT1 in the proximal tubule of the kidney (Mishima et al., 2020)

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