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299 , H1568H1576 (2010)

It usually reflects cumulative stress on detoxification and antioxidant systems

Refluxed blood promotes the Fenton reaction, terminating in the production of hydroxyl radical, the most potently destructive ROS

Proc Natl Acad Sci U S A 75(4):1938-42, 1978

confirmed the enhanced percentage of eryptosis in HD patients and reported a positive correlation between the percentage of circulating eryptotic cells and ROS and ceramide concentrations, and between the percentage of PS-exposing erythrocytes and both erythropoietin dosage and the percentage of reticulocytes [265]

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