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Membrane binding of hemichromes, complement C3 fragment, autologous IgG, and phagocytosis in ring stage-infected GR-deficient RBCs Membrane-bound hemichromes, indicators of oxidative membrane damage and inducers of RBC membrane modifications producing enhanced phagocytosis [20][22], were measured in ring stage-infected RBCs of the index patient, individual 2 (brother), and individual 3 (sister), all homozygous for the GR deficiency, and were compared to ring stage-infected normal RBCs