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Nausea and other GLP-1 side effects can feel more pronounced during certain cycle phases in some individuals, particularly when progesterone peaks

- Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

The active ingredient in Ozempic is semaglutide, a GLP-1 receptor agonist, and it also contains inactive ingredients such as sodium chloride, disodium phosphate, and water for injection, which help stabilize the formulation for subcutaneous use

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Or, the peptides may not be in a form that can be absorbed by the skin