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A randomized, double-blind, placebo-controlled crossover trial found that prebiotics increased postprandial GLP-2 and improved glucose regulation in patients with type 2 diabetes

Patients with a history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe pancreatitis, or uncontrolled diabetic retinopathy should not use GLP-1 therapy

Results regarding the efficacy of mitochondrial modulators against OCD were noted to be inconsistent among the double-blind, randomized, placebo-controlled trials (Table 1), and so it remains unclear whether mitochondrial modulators are beneficial in the treatment of OCD

doi:10.1016/S0022-3565(25)05394-7

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