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Semaglutide is FDA-approved and commercially available in multiple formulations (Ozempic, Wegovy, Rybelsus)

Plasma highsensitivity Creactive protein levels decreased significantly by 53.8 mg/L with semaglutide versus 19.8 mg/L with placebo, indicating reduced systemic chronic inflammation

The two drugs have similar lists of potential side effects

At beginning and end point of the study, inflammatory markers (CRP, erythrocyte sedimentation rate (ESR)), oxidative stress status (total oxidative stress (TOS), total antioxidant capacity (TAC)), and clinical variables will be evaluated also

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Florell, S