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To test whether this increase was due to selection of phenotypically high-GSH producers rather than a generic response (e.g
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MHRA position)
However, there are some indirect evidences supporting that inhibition of HDAC by VPA can enable methylated DNA to be more accessible to DNA demethylase, leading to DNA demethylation [135], which suggests that the induction of the methylation of Scn3a promoter by VPA is likely to be affected by the regulation of HDAC