Thus, while cellular studies indicate low toxicity and functional potential, further in vivo studies are required to assess distribution, metabolism, and clearance, as well as their long-term effects on organs and immune response (Table 3)
(2021) employed tandem mass tag proteomics (TMT) and mass spectrometry (MS) to analyze PBMC, identifying differential expression of proteins regulated by the liver X receptor-retinoid X receptor (LXR/RXR) pathway, which modulates lipid metabolism and inflammation, potentially influencing the expression of pro-inflammatory cytokine genes (Schulman, 2017)
Throughout the last two decades, other proteins have become implicated in these pathways, such as MAG and OMGp, although Nogo-A has remained the most relevant in experimental and clinical investigation
Wingler K, Bocher M, Flohe L, Kollmus H, Brigelius-Flohe R
Huang, H., Yarmush, M
Targeted studies observations were not confirmed in any of the study included in this EWAS analysis (Fig
