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Side-effect profile observed in research Nausea, diarrhoea, constipation, and vomiting were the most frequently reported events in the Phase 2 trial, generally mild-to-moderate and most common during the dose-escalation phase

32 The primary outcome for the trial was the first occurrence of a major adverse cardiovascular event (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke)

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