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This lively debate underscores the importance of accurate parameters when extrapolating in vitro enzyme data: the two hypotheses are not mutually exclusive, but remind us that we must directly and precisely quantify substrate concentrations in the mitochondrial matrix when constructing physiological models

Reduced L-glutathione is the bioactive form as it is also produced by the body itself

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Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicle

Statistical analyses were performed using the Prism software (9.2.0), unless otherwise specified in the figure legends

Vitrified specimens and data collection Holey TEM grids (Ultrafoil R1.2/1.3 Au 300 gold foil grids, Quantifoil GmbH) were pre-washed with chloroform prior to glow discharged