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By chemically modifying the cysteine sensors of KEAP1, thereby releasing NRF2 from KEAP1-mediated ubiquitination, SFN is one of the most potent NRF2 activators [100,101]

The significant demyelination in the CC and PFC may play essential roles in developing depressive-like behaviors, and the beneficial effects of ALC in accelerating the remyelination process may be attributed to providing the necessary energy in this demyelinated mouse model of MS