The low CSF-to-plasma ratio of compound D and the absence of compound Q in CSF may suggest the need for Phase Ib dosing studies to explore novel strategies for increasing Q bioavailability and D levels in the CNS
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J Intern Med 231:567570 Moling O, Cairon E, Rimenti G, Rizza F, Prister R, Mian P (2006) Severe hepatotoxicity after therapeutic doses of acetaminophen
The authors inferred that the increased plasma Met concentration in the RPM group, likely supplied the elevated demand in the mammary tissue required to synthesize cytoprotective proteins, such as heat-shock proteins, which are necessary for cellular defense against thermal stress (Pate et al., 2021)