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Injectable semaglutide may have a practical advantage because once-a-week dosing is easier to maintain consistently than daily tablets, which require strict adherence

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While pharmacological treatment remains essential for mood stabilization, systematic metabolic monitoring is crucial to mitigate treatment-related risks

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Semaglutide reduced systolic blood pressure by 3.3 mm Hg, high-sensitivity C-reactive protein by 37.8%, and improved lipid profilesall achieved on top of high baseline rates of evidence-based cardiovascular therapies (90% on statins, 86% on antiplatelet agents).[1] These pleiotropic effects likely contribute to cardiovascular risk reduction through mechanisms distinct from adiposity changes, supporting the reconceptualization of GLP-1 receptor agonists as cardiovascular disease-modifying agents rather than simply weight-loss medications