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The Mayo Clinic said the supplement "may be safe when taken in recommended amounts" with the main side effects including nausea, constipation, diarrhea, gas and vomiting

Exposures at the no observed adverse effect level in all species were subclinical or only slightly higher than the plasma AUC at the maximum recommended human dose

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Weight Loss Efficacy of Tirzepatide Compared to Placebo or GLP-1 Receptor Agonists in Adults With Obesity or Overweight: a Meta-Analysis of Randomized Controlled Trials With 20 Weeks Treatment Duration

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These findings suggest that GLP-1 RAs confer modest BP-lowering effects as adjuncts to standard antihypertensive therapy in individuals with T2DM at elevated cardiovascular risk