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Administration of exendin-4 ameliorated stress-induced defecation, decreased visceral pain sensitivity and increased the serum level of anti-inflammatory cytokine: interleukin-13 in the WistarKyoto rat strain, which was considered a model for irritable bowel syndrome [116]
Published trials showed that the treatment with GLP1-RA reduced the risk of MACE and slowed the development of albuminuria in diabetic patients, demonstrating a direct cardio and reno-protective action of GLP1-RA, regardless the effect on glycemic control (60, 61)
Because these are powerful biological signals, they must be prescribed by a licensed healthcare provider following a medical consultation and lab review