PMID: 34349821
The presence of the specialized tripeptide KPV allows researchers to monitor the competitive downregulation of nuclear factor kappa B (NF-kB) and trace the inhibition of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) within inflamed intestinal or cutaneous tissues
Studies have shown that GLP-1RA affects the key phases by reducing its main cytokines and chemokines, such as TNF, IL-6, IL-10, and IL-12, and MCP-1, leading to a reduced inflammatory state, improved endothelial function, and promoted cholesterol efflux
For persistent bile acid diarrhoea, your GP may refer you to a gastroenterologist for assessment (potentially including SeHCAT testing) and consider bile acid sequestrants such as colestyramine
As the population of older adults grows and the wider clinical acceptance of therapies increases, the adoption rate is speeding up
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