GLS1, which converts glutamine to glutamate, is crucial for CRC survival
Penugonda S, Mare S, Goldstein G, Banks WA, Ercal N
The product can be obtained in its alpha crystalline form from said concentrated solutions by leaving crystallisation to initiate spontaneously, without adding ethanol or other solvents, or by seeding with alpha-form crystals
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Chem-Eur J
Similar trends were observed in a mouse model of pancreatic ductal adenocarcinoma (PDAC) ( LSL-Kras G12D/+ Trp53 f/f Pdx1 cre (KP / C) mice 28 ) and in humans with renal cell carcinoma 29 (Extended Data Fig