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The determination of the rate constants for the reaction of DSePA with hydroperoxides versus thiols, along with the characterization of reaction intermediates, suggested that the entry of DSePA into the GPx cycle followed an oxidative rather than a reductive pathway (Fig

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Further, targeted metabolomics revealed that MOTS-c treatment significantly regulated (i) glycolysis/PPP (pentose phosphate pathway) and (ii) amino acid metabolism (Fig