Quick Summary: Semaglutides weight loss over 3 months varies by dose and individual factors but many adults in clinical trials lose significant weight (often mid-teens percentage of baseline body weight) with adherence to dosing and supportive lifestyle changes
For tirzepatide versus semaglutide, contrary to the primary endpoint in the head-to-head comparison, there was some supporting evidence for tirzepatide to have a modest benefit, although the 95% CI overlapped the null (HR 0.91, 95% CI 0.81 to 1.01) (Fig
10.3389/fendo.2023.1085799
Skin fragility : Older adults or those on long-term corticosteroids may have thinner, more fragile skin
Studies in adults also indicate the peptides safety, primarily reporting injection site reactions such as [14, 15]: Pain Swelling Inflammation Induration Bleeding A 16-week sermorelin study also observed temporary hyperlipidemia in some participants, possibly due to increased fat release from adipose cells [17]
This is unlikelyeven for patients with pre-existing conditionsbut is possible in some cases