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It made me so mad, she says

The MNX mouse is a model of mtDNA polymorphism, in which the nuclear genome from one mouse strain is transferred into an enucleated recipient zygote of a different mouse strain, thus allowing each progeny to distinctly have 100% of the nDNA and mtDNA from their respective donor strains (C57BL/6J and C3H/HeN) [15]

The base mechanism is identical, so if the modified versions really do achieve substantially higher effective tissue concentrations per administered milligram, then a lower administered dose makes sense

Tanemura, Y., Murakami, K., Haneda, M

Berthoud, H

doi: 10.1177/0148607189013006663