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These findings suggest that GLP-1 receptor agonists, particularly at higher doses, may offer disease-modifying benefits beyond symptomatic improvement

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In the IMPACT trial, pemvidutide achieved mean weight losses of 4.8% and 5.8% with 1.2 and 1.8 mg doses respectively at 24 weeks, compared to 0.5% with placebo, with weight loss curves showing no evidence of plateauing, suggesting continued benefit with longer treatment [49-51]