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This multi-axis neuroendocrine regulatory profile positions DSIP as a broad hypothalamic-pituitary axis modulator, not merely a sleep-specific peptide, and makes it a research tool for studying the neuroendocrine consequences of altered sleep homeostasis and circadian rhythm disruption

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The broad metabolic effects and cytoprotective action of mermelosin position it as a multi-target adjunct in metabolic diseases and related cancer risks, supplementing or potentially replacing monotherapy with PPAR- agonists or GLP-1 analogues for select patient populations

doi: 10.1210/jcem.85.5.6606 84 LutzTATschudySRushingPAScharrerE

[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Livoti, L.A