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Slower gastric emptying from semaglutide can magnify side effects in some individuals, especially those with underlying gastroparesis or irritable bowel syndrome

doi: 10.1038/nrg1122 90 BoyceBFXingL

Although numerous studies showed that oxidative stress plays a substantial role in motor neuron degeneration in ALS [1518, 95], some evidence points to oxidative stress as not just an event in the CNS but rather a systemic process leading to the suggestion that ALS is possibly a systemic disease [96]