The distinct contributions of each receptor system - GLP-1-mediated improvements in insulin sensitivity and appetite regulation, GIP-mediated enhancement of insulin secretion and adipose tissue function, and glucagon-mediated direct hepatic metabolic modulation and increased energy expenditure - create synergistic benefits when engaged through dual or triple agonist formulations
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Hucking K, Kostic Z, Pox C, Ritzel R, Holst JJ, Schmiegel W, Nauck MA
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