This condition is prevalent in about 8% of adult women, although it isnt talked about much.[ref] Animal studies show certain preservatives often used in body washes and shampoos can cause increased vaginal mast cells and eosinophils and had higher serum Immunoglobulin E
Moreover, the number of LDL-C B/E receptors on the cell surface is considerably diminished,[] which may be due to a decrease in the expression of insulin and can lead to disruption of LDL-C catabolism.[ , ] Changing LDL-C compositions may cause conformational changes and probably results in higher exposure of fatty acids to oxygen-free radicals and changes in lipid peroxidation levels.[ , ] In plasma or subendothelial arterial wall, uptake of LDL-C will increase via scavenger receptors present in macrophages, smooth muscle cells, and endothelial cells as consequences of LDL-C oxidation.[ , , , ] The formation of foam cells as well as the alteration of monocytes and macrophages in the arterial wall to cholesterol foam cells, which are essential parts of the atherosclerosis plaque, significantly increases with the oxidative changes in LDL-C.[ , ] Moreover, in individuals with diabetes, levels of serum lipids are often elevated and are independently related to some complications of DM.[ , ] Higher levels of insulin in the blood, the presence of non-oxidative glycation products, and increases in levels of blood glucose[] because of insulin resistance may increase the risk of cardiovascular morbidity in type 2 diabetes.[] The risk of oxidative stress, which has a vital role in LDL-C oxidation and hyperglycemia, is high in individuals with diabetes.[ , ] Many pharmacological agents, such as calcium channel antagonists and antiplatelet[] agents, have been used in the treatment of peripheral arterial disease (PAD) in individuals with diabetes
A., Wang, R., Ju, Y
Its stability relies upon the quality of storage area and packaging of formulation
The trial was performed in accordance with the guidelines established by the Declaration of Helsinki and the International Conference on HarmonizationGood Clinical Practice
Farokhnia M, Leggio L
