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Further, targeted metabolomics and isotope tracing experiments uncovered GGCT as a metabolic orchestrator to prioritize Gln to GSH flux for antioxidant defense, while activating glucose (Glc)-fueled anaplerosis to replenish TCA intermediates to fuel proliferation

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[Abstract] J Transl Med

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We hypothesize that 10 M curcumin is already in excess compared to free iron, especially if curcumin can cycle the iron to transferrin and maintain it in the redox inactive state 52