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203-205 Another open-label controlled trial in 24 stable stage 34 CKD patients found that a low-protein diet supplemented with a synbiotic formula for six months resulted in a slower decline in GFR than a low-protein diet alone during one year of monitoring

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TMP significantly reduces the expression levels of pro-inflammatory factors TNF-, IL-1, and IL-6 by inhibiting signaling pathways such as NF-B, while simultaneously upregulating the synthesis of tight junction proteins Zonula Occludens-1 (ZO-1) and Occludin, thereby maintaining the structural integrity of the intestinal epithelium (Tung et al., 2025)

pylori display high genetic diversity, which has resulted from the extraordinarily high homologous recombination and mutation rates (Vital et al

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It arises from chronic energyprotein deficiency, systemic inflammation, and endocrine alterations, and mediates the link between traditional nutritional indicators and postoperative outcomes (e.g., infections, delayed wound healing and prolonged recovery)