Luo et al found that TMAO may inhibit the expression of nuclear factor E2-related factor 2 (Nrf2), HO-1, and glutathione peroxidase 4 (GPX4), resulting in the overproduction of ROS and the reduction of SOD activity, thus promoting oxidative stress
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The findings of this meta-analysis suggest that GLP-1 receptor agonists are not associated with an increased risk of gastrointestinal cancers and were not associated with increased gastrointestinal cancer risk and demonstrated pooled estimates below unity for colorectal and liver cancers, findings that should be interpreted as hypothesis-generating rather than confirmatory of cancer prevention ( Notably, our subgroup analysis showed greater protective effects in older adults and obese individuals, two populations already at heightened risk for gastrointestinal cancers
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