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Given that impaired autophagy and dysregulated mucin secretion are key contributors to barrier dysfunction, TB-500s regenerative and anti-inflammatory actions may indirectly support mucin2 production and mucus layer integrity, though direct evidence in colitis models remains limited

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10.1038/nrmicro3016 82 SaracinoI

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There was also an increase in TNF-a, NO, and malondialdehyde levels, indicating a global negative effect on both exocrine and endocrine functions of the gland