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LC-MS chromatograms of each group of gastric tissues in positive mode have been shown in Figure S3(a)

Despite its therapeutic efficacy, tacrolimus has a narrow therapeutic window (520 ng/mL whole blood 1012 h post-dose) and frequently displays episodes of toxicity, such as nephrotoxicity, neurotoxicity, and glucose intolerance (Malaekeh-Nikouei and Davies, 2009)

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