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Although E2 has a stronger binding affinity than E3, unlike E2, E3 can accumulate in significant amounts in target organs to activate ER receptors [58, 59]

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Biomarkers in Vitiligo IFN- : A Key Player in Melanocyte Destruction Melanocyte depletion in vitiligo is primarily caused by cytotoxic T lymphocytes (CTLs), with activation of the FasFasL pathway being a key molecular mechanism

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