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Physiology-Renal Physiology 310 (2), F123F127

GLP-1 medications reshape metabolism quickly

How does dosing frequency (daily versus weekly) affect the choice

Heerspink, 25 October 2024, Nature Medicine

It also slows how quickly the stomach empties, which helps you feel fuller for longer and reduces how much you feel the need to eat

Note that with this method of delivery absorption occurs predominantly in the stomach to achieve therapeutic plasma levels, and overcomes otherwise insurmountable challenges of peptide absorption related to solubility, molecular size, and enzymatic degradation in the protease-rich environment of the small intestine (Buckley et al, 2018)