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The reduced form of doxorubicin, resulting from AKR1C3 activity, exhibits lower affinity and capacity to bind to DNA (Heibein et al., 2012)

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Li JM, Li LY, Zhang YX, Jiang ZY, Limbu SM, Qiao F, Degrace P, Chen LQ, Zhang ML, Du ZY (2019a) Functional differences between l- and d-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model

Choline supports phosphatidylcholine synthesis

The adverse reactions described in Table 1 below are based on data from an eight week cross over trial in which vitamin B12 deficient patients in hematologic remission received one vitamin B12 intramuscular injection (N=25) and then received once weekly intranasal administration of another nasal cyanocobalamin formulation (N=24) for 4 weeks

Furthermore, a combination from buffering agents such as phosphate buffered saline and a saline and acetate buffer can be used