evidence is largely preclinical Potent growth-factor signalling can affect blood glucose (hypoglycaemia risk) and involves proliferative pathways that need clinical oversight Screening, suitability and any monitoring are determined by the treating physician Clinical note: This card is educational and is not medical advice, a protocol or a promise of results
Safety concerns with GLP-1 and DPP-4 combination use include heightened gastrointestinal side effects (nausea, vomiting, diarrhea), potential pancreatitis risk (though rare), and drug interaction considerations
Salinas et al 27 The traditional treatment of vitamin B 12 deficiency is the intramuscular injection of cyanocobalamin, generally, 1 mg/d for 1 week, followed by 1 mg/wk for 1 month, and then 1 mg every 1 or2 months ad perpetuum
Additional Health Benefits
The effects of ER once-weekly have been compared to exenatide twice-daily and overall ER was more effective at improving glycemic control and caused less gastrointestinal side-effects although both compounds caused a similar degree of weight loss (Drucker et al., 2008
Working closely with a healthcare provider can help you find the right approach for your unique needs