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967 They are remarkable examples of the extent to which evolution has gone to maintain the catalytic power of cellular metabolism dependent on metalloenzymes, particularly those enzymes involved in central carbon metabolism, one-carbon shuttling, scavenging of reactive oxygen species, and diverse aspects of the central dogma, when critical nutrient metals are in short supply
For instance, Baggott and colleagues (175) gave rats meals containing varying amounts of folic acid (0, 2, or 40 mg/kg diet) or folinic acid (20 mg/kg diet)
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In pathological situations, such bidirectional immunological conditions can substantially target the immune system
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Drablos et al., 1997
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