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Mitochondrial dysfunction has been suggested to contribute to CFS (5962)]

42 The myenteric plexus, located between the longitudinal and circular muscle layers and extending from the esophagus to the rectum, spans the entire digestive tract

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3 However, muscle soreness is separate from DOMS, which is caused by micro tears

Available treatments such as levodopa, dopamine agonists and monoamine oxidase B inhibitors offer only symptomatic relief however, they do not treat the underlying neurodegeneration, emphasising the need for neuroprotective management