GSH is a tripeptide (-L-glutamyl-L-cysteinyl-glycine) and is considered the predominant non-protein thiol in mammalian cells, working alone or in concert with enzymes to reduce superoxide radicals, hydroxyl radicals, and peroxynitrites.42 The intracellular balance and optimal concentration of GSH, as well as its redox ratio, are critical components of redox homeostasis in healthy cells.43 In this study, both melatonin and GSH administration were found to restore the disrupted levels of GSH-Px, SOD, and CAT in the CARB-treated group, supporting their role in maintaining antioxidant defense
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Moreover, qRTPCR showed that the silica-stimulated MCM-induced transcription of the fibrotic genes -SMA, collagen I and Fn was also inhibited by liraglutide (Fig
The ratio of GSH to GSSG is a key indicator of cellular oxidative stress, with a healthy cell maintaining a ratio greater than 100:1 [2][5]
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