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It not only provides the material and energetic basis for the unlimited proliferation of tumor cells, but also reshapes the tumor immune microenvironment (TIME) by regulating metabolite levels (including lactate, glutamate, serine, etc.) and mediating epigenetic modifications such as histone lactylation and methylation

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The combined rationale assumes these mechanisms may work synergistically

NICE does not recommend afamelanotide for routine NHS use in England

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Melatonin acts as an effective scavenger of reactive oxygen species, modulates the immune response, protects mitochondrial integrity, and improves blood flow