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Early Discoveries, With More to Come So far, GLP-1s, first approved 20 years ago for type 2 diabetes and later obesity, have shown potential in treating a surprisingly wide range of conditions, such as heart disease, Parkinsons, Alzheimers, sleep apnea, and liver disease

doi: 10.1016/j.metabol.2010.09.010 57 SimpsonSHMajumdarSRTsuyukiRTEurichDTJohnsonJA

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However, its off-label use for performance enhancement in bodybuilding falls outside approved indications and may carry legal and regulatory risks

MS: literature search, data analysis, and original draft preparation