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Creatine monohydrate supplementation (3-5 grams daily) combined with resistance training may help preserve skeletal muscle during caloric restriction by supporting ATP regeneration in muscle cells

However, some studies and patient reports suggest that non-diabetic individuals might still experience side effects like hot flashes, though these might be less common or less intense

It increases hepatic glucose output in the short term, which sounds counterintuitive for a metabolic drug, but the body compensates through increased energy expenditure

Extracting extra or fractional doses from pens defeats the devices design, risks contamination, and can derail titration

Gogineni P, Melson E, Papamargaritis D, Davies M