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Most participants in trials reached 812 mg weekly, which delivered the strongest results Dosing protocols may be refined in Phase 3 and post-approval, but gradual titration will remain the standard
Cognitive effects of estradiol after menopause: a randomized trial of the timing hypothesis
inhibition of VMAT2 reduces available dopamine that can be released into the synaptic cleft, which can reduce the symptoms associated with dopamine hypersensitivity
Chen TH, Lin SH, Lee MY, Wang HC, Tsai KF, Chou CK
Aakre, I