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Specifically, the vaping liquids with vanillin and ethyl vanillin inhibited MAO and could potentially enhance the response to nicotine and increase addiction.[ref] Circling back to Parkinsons: Avoiding Paraquat I mentioned above that MAOB converts the chemical MPTP into a neurotoxic substance, MPP+, which is used to create animal models for Parkinsons research

A summary of this mechanistic process is shown in Figure 1 below

Inhibition of AKT activation by IGF-1R inhibitor, OSI-906, is supposed to suppress p70S6K1 activation