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From an aesthetic perspective, this matters because: GLP-1 RAs influence body composition, reducing lean mass, which might alter diffusion or uptake of injectables They impact systemic metabolism which may alter the pharmacokinetics or pharmacodynamics of other drugs As more patients on GLP-1 therapy request cosmetic injectables, including botulinum toxin, the potential for interaction becomes clinically relevant
Over time, they have also proven to be highly effective for weight loss
Kitzman DW, Brubaker P, Morgan T et al (2016) Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial
Retatrutide is the agonist of GLP-1 receptor, GIP receptor, and glucagon (GCG) receptor, which can reduce body weight and improve blood glucose by subcutaneous injection once a week(Rosenstock et al 2023)
The Reflexive Nature of a Successful Weight Loss Drug The exponential rise in search trends for terms related to these drugs (GLP-1, Wegovy, Mounjaro, Ozempic) speaks to a reflexive relationship that is catalyzed by the nature of social media
We are learning more about side effects of these drugs as they come into more use
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