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In addition to TfR, the other extensively investigated receptors and transporters for brain targeting are LDL receptor and glucose transporter

Glutathione conjugates with acetaldehyde via glutathione S-transferase (GST), forming a mercapturic acid derivative that the kidneys excrete

Two pharmacokinetic characteristics play a crucial role, i.e., the prediction of gastrointestinal passive absorption and the permeability of the BBB 40

Genetic deletion of GSK3 in mice results in behaviours that mimic the mood-stabilising effects of lithium, as well as causing cognitive deficits similar to those associated with chronic lithium treatment in humans [166,167,168,169]

Transdermal Patch Delivery: Offers a noninjectable route for peptide administration with steady peptide release over several hours

Scale bars, f , j and h , l , 200m